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Istituto Superiore di Sanità
EpiCentro - Epidemiology for public health
Epidemiology for public health - ISS

Surveillance of bacteraemias caused by carbapenem-resistant Enterobacteriacea

The surveillance of bacteraemias caused by carbapenem-resistant Enterobacteriaceae (CRE), established by a Ministry of Health circular in 2013 as a surveillance of bacteraemias caused by carbapenemase-producing Enterobacteriaceae (CPE), collects and analyzes reports of carbapenem-resistant and/or carbapenemase-producing Klebsiella pneumoniae and Escherichia coli bacteraemias from across the country. The objective is to monitor frequency, trends over time, spread and evolution of these infections, and to develop appropriate containment strategies. The surveillance protocol was updated by a ministerial circular issued in 2019, and a dedicated web-based platform was created for reporting cases.


Analyzed data are based on anonymous and individual reports sent by hospitals/hospital trusts and Local Health Units to the Ministry of Health and the Istituto Superiore di Sanità (ISS), where they are collected, recorded in a dedicated database and analyzed by the Department of Infectious Diseases of the ISS.


Every year, the collected data are published in an online report.


Publication date: 4 January 2021