Italian Haemolytic Uraemic Syndrome Registry
The Italian Haemolytic Uraemic Syndrome (HUS) Registry collects information on cases of this condition reported across the country. Data are recorded systematically and continuously. The registry is operated by the Italian Society of Paediatric Nephrology (Società Italiana di Nefrologia Pediatrica - SiNePe), in collaboration with the Istituto Superiore di Sanità (ISS). Cases of the disease are mainly reported by the paediatric and adult nephrology centres participating in the surveillance, through the HUS Registry information system (ISSEU).
Report / 1 December 2020 – 30 November 2021
HUS is considered a rare condition. In Italy, 54 cases were recorded between 1 December 2020 and 30 November 2021. Patients were from 14 different Regions. Of the 54 cases, 53 (98%) were recorded, as expected, in the paediatric population (<15 years of age). Over the last 12 months, the average notification rate for this age group has been 0.64 cases per 100,000 residents, with marked regional variations. The highest rate was observed in Apulia (1.8 cases per 100,000 residents). In this and six other Regions or Autonomous Provinces (Liguria, Emilia-Romagna, Piedmont, Lombardy, Friuli-Venezia Giulia and Autonomous Province of Bolzano), the notification rate was higher than the national average.
The number of HUS cases reported to the Italian Registry in the three months between September and November 2021 was 26.3% lower than expected, dropping to 12 from an average of 16.3 cases for the same period in the previous 10 years. Figures for the six months between December 2020 and May 2021 were also lower than the expected total for that time of year. By contrast, the number of HUS cases reported in June-August 2021 was slightly higher than expected: in August 2021, in particular, it was 18% higher than the average for that month in the previous 10 years.
HUS is known to predominantly affect the paediatric population (<15 years of age), and is often developed in the earliest years of life. The median age of clinical onset among the cases reported between 1 December 2020 and 30 November 2021 and in the previous 10 years was 22 months and 32 months, respectively. Only 1 HUS case was reported in the adult population between 1 December 2020 and 30 November 2021 (2% of the total).
Distribution by sex showed no significant differences between males and females.
- Italian Haemolytic Uraemic Syndrome Registry: Report archive
- Pages about the Italian Haemolytic Uraemic Syndrome (HUS) Registry on EpiCentro and on the ISS website
- Website of the Italian Society of Paediatric Nephrology (SiNePe)
- Website of the HUS Registry Information System (ISSEU)
- Website of the National Reference Laboratory for E.coli of the ISS
- For further information, please contact the HUS Registry by sending an email to: firstname.lastname@example.org
Note 1: HUS (Molecular Epidemiology and Public Health Laboratory, University of Bari; Microbiology Laboratory of the Ca’ Granda Ospedale Maggiore General Hospital, Milan)